Cancer Research

Seminars

11-13 May, 2009: Attendance of a course: “2nd Course of in vivo Preclinical Assays in Cancer Therapy”, INSTITUT CURIE, Paris, France

7-28 April, 1997: Participation in the Seminar for Prostate Cancer at the Department of Clinical Chemistry, Pathology, and Laboratory Medicine at the School of Medicine at UCLA, USA (Instructor: J. McBride)

 

Research Grants

As Principal Investigator

08/ 2006-08/ 2008: “Establishment of experimental models for carcinogenesis: histological and electrophysiological parameters” Sanofi-Aventis, Code of AUTh Research Committee: 81948

06/2004-02/2006 “Establishment of a Waldenström’s Macroglobulinemia Animal Model” International Waldenström’s Macroglobulinemia Foundation (IWMF), Code of AUTh Research Committee: 21962

 

Member of Advisory and Examining Committees

Member of the Ph.D. Advisory Committee and Examining Committee for the medical doctor Dimitrios Giakoumettis with the title: «Experimental study of the action of the Crocus Sativus Linneaus extract in brain glioblastomas», School of Medicine, Faculty of Health Sciences, AUTh (2013 – 2019)

Member of the Ph.D. Examining Committee for the veterinarian Elisavet Karamanavi, with the title: «The role of urokinase-type plasminogen activator in the pathogenesis of colitis», School of Veterinary Medicine, Faculty of Health Sciences, AUTh, 2013

Member of the Ph.D. Examining Committee for the veterinarian Michael Doulberis, with the title: «The effect of cholera toxin-induced intestinal immune system activation on the pathogenesis of murine colitis and large bowel adenocarcinoma», School of Veterinary Medicine, Faculty of Health Sciences, AUTh, 2013

Member of the Master’s Advisory and Examining committee for the physical education graduate Eudoxia Deligianni, with the title: «Investigation of the connection ratio of the length of the 2nd and 4thdigits with demographic and clinical characteristics of patients with breast cancer», School of Physical Education, AUTh (2007 – 2008)

 

Books

Chapter

Animal models of lymphoproliferative disorders focusing on Waldenström’s macroglobulinemia (2012). In: Hematology-Science and Practice, Ed. C.H. Lawrie, ISBN 978-953-51-0174-1, pp. 425-466, InTech (Intechweb.org). Available from: http://www.intechopen.com/books/hematology-science-and-practice/animal-models-oflymphoproliferative-disorders-focusing-on-waldenstro-m-s-macroglobulinemia

 

Publications

Pseftogas, A.; Xanthopoulos, K.; Poutahidis, T.; Ainali, C.; Dafou, D.; Panteris, E.; Kern, J.G.; Varelas, X.; Hardas, A.; Gonidas, C.; Α. S. Tsingotjidou; Hatzivassiliou, E.; Mosialos, G. (2020). The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF Signaling. Cancers 2020, 12, 2047.

Nikistratos Siskos, Chryssa Bekiari, Theophilos Poutahidis, Alexandros Chadras, A. S. Tsingotjidou (2019) Monitoring Mast Cell Populations in Waldenström’s Macroglobulinemia: A Xenotransplantation Study. Journal of Hematalogy and Oncology Research – 3(3):9-20.  DOI 10.14302/issn.2372-6601.jhor-19-3092

Doulberis M., Angelopoulou K., Kaldrymidou E., Tsingotjidou A., Abas Z., Erdman S.E., Poutahidis T. (2015). Cholera-toxin suppresses carcinogenesis in a mouse model of inflammation-driven sporadic colon cancer. Carcinogenesis. 36(2):280-290

Karagiannis G.T., Grivas I., Tsingotjidou A., Apostolidis G.K., Grigoriadou, I. Dori I., Poulatsidou K.-N., Doumas A., Wesarg S. and Georgoulias, P. (2015) Early detection of melanoma with the combined use of acoustic microscopy, infrared reflectance and Raman spectroscopy Proc. SPIE BiOS, Photons Plus Ultrasound:  Imaging and Sensing 93232T-93232T -9

Karamanavi, E., Angelopoulou, K. Lavrentiadou, S., Tsingotjidou, A., Abas, Z. Taitzoglou, I., Vlemmas, I., Erdman, S. E., Poutahidis, T. (2014). Urokinase-Type Plasminogen Activator Deficiency Promotes Neoplasmatogenesis in the Colon of Mice. Translational Oncology, 7 (2): 174-U179.

Tsingotjidou A. S., Emmanouilides CE, Siotou E, Poutahidis T, Xagorari A, Loukopoulos P, Sotiropoulos D, Bekiari C, Doulberis M, Givissis P, Fassas A, and Anagnostopoulos A. (2009). Establishment of an animal model for Waldenstrom’s macroglobulinemia. Exp Hematol, 37(4):469-476.

Tsingotjidou, A. S., R. Ahluwalia, J. Zhang, H. Conrad, and C. Emmanouilides (2003). A metastatic human prostate cancer model using intraprostatic implantation of tumor produced by PC-3 neolacz infected cells. Int. J. Oncology, 23(6):1569-1574.

A.S. Tsingotjidou, G. Zotalis, K. R. Jackson, C. Sawyers, J. E. Puzas, D. G. Hicks, R. Reiter, and J. R. Lieberman (2001). Development of an Animal Model for Prostate Cancer Cell Metastasis to Adult Human Bone. Anticancer Res., 21 (2A):971-978.


Publications in bone (metastatic tissue of primary malignancies)

Tintut, F. Parhami, Tsingotjidou, A. S., S. Tetradis, M. Territo, and L.L. Demer (2002). 8-Isoprostagladin E2 enhances RANKL-dependent osteoblastic potential of marrow hematopoietic precursors via the cAMP pathway. J. Biological Chem., 227(16): 14221-14226.

Tsingotjidou, A. S., J.M. Nervina, L.Pham, O.Bezouglaia, and S. Tetradis (2002). Parathyroid hormone induces RGS 2 expression by a cyclic-Adenosine 3,5-Monophopshate-mediated pathway in primary neonatal murine osteoblasts. Bone, 30 (5):677-684.

Tetradis, O. Bezouglaia and Tsingotjidou, A. S. (2001). Parathyroid hormone induces expression of the nuclear orphan receptor Nurr1 in bone cells. Endocrinology, 142(2):663-670.

Tetradis, O. Bezouglaia, Tsingotjidou, A.S., and A. Vila (2001). Regulation of the nuclear orphan receptor Nur77 in bone by parathyroid hormone. Biochemical and Biophysical Res. Communications, 281:913-916.

 

Invited speaker

9th World Congress on Advances in Oncology, and 7th International Symposium on Molecular Medicine, Hersonissos, Crete: “The voyage of cancer”, 20

 

Presentations in meetings

Konstantinos Bourtzinakos, Tryfon Chatzimanou, Charis Pappas, Avraam Tsitalkidis, Nikolaos Foroglou, Alexandra Palaiologou, George Gavriilidis, Nikoleta Melemeni, and Anastasia S. Tsingotjidou, Histological and immunohistochemical characteristics of human glioblastoma 28th Meeting of Ηellenic society for neurosciences, Heraklion – Greece (2019).

Karagiannis G., Apostolidis G., Vavliakis K., Grivas Ioannis, Tsingotjidou Anastasia, Dori Ioanna, Georgoulias P. (2015). Use of signal processing techniques applied to acoustic microscopy echo graphs in order to support the detection of melanoma infiltration using time frequency representation techniques. 6th Hellenic conference in biomedical technology. Athens – Greece.

Karagiannis G., Grivas G., Tsingotjidou A., Apostolidis G., Doumas A., Wesarg S., Georgoulias P. 3D spectroscopic mapping imaging for early detection of melanoma. 4th Hellenic Congess on oncological imaging, 17-19 December 2015, Thessaloniki, Greece.

Siskos N., Bekiari Chrysanthi, Tsingotjidou Anastasia. (2015). Comparative study of mast cells’ populations on an animal model for Waldenströms Macroglobulinemia. 13th Meeting of the Hellenic Veterinary Association. Athens – Greece.

Grivas Ioannis, Karagiannis G., Tsingotjidou Anastasia, Dori Ioanna, Grigoriadou I., Wesarg S., Georgoulias P. (2014). Experimental model for the study of melanoma. Diagnostic approach with the combined use of acoustic microscopy and infrared spectroscopy, evaluated by histological analysis. Annual Meeting of the Hellenic Society of Biomedical and Laboratory Animal Science. Athens – Greece.

Karagiannis G., Tsingotjidou Anastasia, Grivas Ioannis, Grigoriadou I., Wesarg S., Georgoulias P. (2014). Development of a non-invasive system for the early detection of melanoma with the combined use of acoustic microscopy from 50 up to 175MHz, IR reflectance from 0.4µm up to 10µm., Raman spectroscopy. 9th International Conference on Ultrasonic Biomedical Micro scanning. Universidy of Edinburgh – Unitied Kingdom.

Doulberis M, Angelopoulou K, Kaldrymidou E, Tsingotjidou A, Abas Z, Erdman SE, Poutahidis T. (2011). Cholera-toxin suppresses carcinogenesis in a mouse model of inflammation-driven sporadic colon cancer. Presented at the 29th Meeting of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists and at the 9th European Congress of Toxicologic Pathology of the European Society of Toxicologic Pathology, Upsala, Sweden

Karamanavi E, Angelopoulou K, Lavrentiadou S, Tsingotjidou A, Abas Z, Taitzoglou I, Vlemmas I, Erdman SE, Poutahidis T. (2011). Urokinase-type plasminogen activator deficiency promotes colitis-associated carcinogenesis in mice. Presented at the 29th Meeting of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists and the 9th European Congress of Toxicologic Pathology of the European Society of Toxicologic Pathology. Upsala, Sweden.

Tsingotjidou, A, Bekiari, C, Kagiava, A, Theophilidis, G, Emmanouilides C. (2009). Αn experimental study for peripheral neuropathy associated with Waldenstrom’s macroglobulinemia. Presented at the 14th Annual Meeting of the European-Hematology-Association, Date: JUN 04-07, 2009 Berlin, Germany and published at the Haematologica-The Hematology Journal: 94 (376), Meeting Abstract: 0934.

A. S. Tsingotjidou, C. E. Emmanouilides, E. Siotou, A. Xagorari, D. Sotiropoulos, T. Poutahidis, P. Givissis, A. Fassas, and A. Anagnostopoulos. (2007). An animal model for Waldenström’s macroglobulinemia. Presented at the XIth International Myeloma Workshop και IVth International Workshop on Waldenström’s macroglobulinemia, Κως and published at the Haematologica-The Hematology Journal: 92 (6): 221, 2007

Tsingotjidou Anastasia (2007). Humanized animal models of cancer metastasis to bone. 10th FELASA symposium. Cernobbio – Italy.

A.S. Tsingotjidou, E. Siotou, C. E. Emmanouilides, D. Sotiropoulos, T. Poutahidis, A. Xagorari, P. Givissis, A. Fassas, and A. Anagnostopoulos. (2006). Development of a NOD-SCID-Hu animal model to investigate Waldenström’s macroglobulinemia. Presented at the 11th Congress of the European Hematology Association, Amsterdam, The Netherlands and published at the Haematologica-The Hematology Journal: 91, Supp. 2 :269, 2006.

A.S. Tsingotjidou and C.E.Emmanouilides (2004). The voyage of cancer. Orally presented at the 9th World Congress on Advances in Oncology, and at the 7th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece and published at Int. J. of Molecular Medicine 14: 28, Supp. 2004.

Tsingotjidou A., Ahluwalia R., Zhang J., Conrad H., Lieberman J. (2000). A metastatic human prostate cancer model using intraprostatic implantation of tumor produced by pc-3 neolacz infected cells. 91st American Association for Cancer Research Annual Meeting. San Francisco, California – USA.

Conrad, R. Ahluwalia, J. Zhang, A. S. Tsingotjidou and J. R. Lieberman (2000). A comparison of metastatic human prostate cancer models using PC-3 neolacZ cells. Presented at theAnnual Medical Meeting of West States of America and published at J. Invest. Med. 48 (1): 466, Supp. 2000.

C. Wang, A. S. Tsingotjidou and J. R. Lieberman (2000). A histological comparison of PC-3 tumor cell invasion of human bone versus pig bone. Presented at theAnnual Medical Meeting of West States of America and published at J. Invest. Med. 48 (1): 466, Supp. 2000.

N. Sjak-Shie, A. S. Tsingotjidou, K. Zhang, R. A. Vescio, J. W. Said, J. R. Lieberman, and J. R. Berenson (1999). Development of a SCID-hu animal model that more closely resembles human multiple myeloma. Presented at The American Society of Hematology Meeting; New Orleans, December, 1999), and published at Blood, 94 (10): 2447 Part 1 Supp., 1999.

Tsingotjidou A., Hicks D.G., Jackson K.R., Zotalis G., Sawyers C., Puzas J.E., Lieberman J.R. (1999). Development of an animal model to assess prostate cancer metastasis to bone. 45th Orthopedic Research Society. Anaheim, CA – USA.

 

Meetings’ attendance

2008: The ESH Euroconference on Multiple Myeloma and other monoclonal gammopathies, Cascais, Portugal

2008: The ESH Euroconference on Multiple Myeloma and other monoclonal gammopathies, Cascais, Portugal

2006: 11th Congress of the European Hematology Association, Amsterdam, The Netherlands

2004: 9th World Congress on Advances in Oncology, and 7th International Symposium on Molecular Medicine, Hersonissos, Crete

2000:   91st American Association for Cancer Research Meeting, San Francisco, CA

1999:   45th Orthopaedic Research Society Meeting, Anaheim, CA